Chronic late-gestation hypoglycemia upregulates hepatic PEPCK associated with increased PGC1 mRNA and phosphorylated CREB in fetal sheep
نویسندگان
چکیده
Paul J. Rozance, Sean W. Limesand, James S. Barry, Laura D. Brown, Stephanie R. Thorn, Dan LoTurco, Timothy R. H. Regnault, Jacob E. Friedman, and William W. Hay Jr. Perinatal Research Center, Department of Pediatrics, School of Medicine, University of Colorado Denver and Health Sciences Center, Aurora, Colorado; Agricultural Research Complex, Department of Animal Sciences, University of Arizona, Tucson, Arizona; and Department of Obstetrics and Gynaecology, University of Western Ontario, London, Ontario, Canada
منابع مشابه
Chronic late-gestation hypoglycemia upregulates hepatic PEPCK associated with increased PGC1alpha mRNA and phosphorylated CREB in fetal sheep.
Hepatic glucose production is normally activated at birth but has been observed in response to experimental hypoglycemia in fetal sheep. The cellular basis for this process remains unknown. We determined the impact of 2 wk of fetal hypoglycemia during late gestation on enzymes responsible for hepatic gluconeogenesis, focusing on the insulin-signaling pathway, transcription factors, and coactiva...
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Hepatic glucose production (HGP) normally begins just prior to birth. Prolonged fetal hypoglycemia, intrauterine growth restriction, and acute hypoxemia produce an early activation of fetal HGP. To test the hypothesis that prolonged hypoxemia increases factors which regulate HGP, studies were performed in fetuses that were bled to anemic conditions (anemic: n = 11) for 8.9 ± 0.4 days and compar...
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We measured in vivo and in vitro nutrient-stimulated insulin secretion in late gestation fetal sheep to determine whether an intrinsic islet defect is responsible for decreased glucose-stimulated insulin secretion (GSIS) in response to chronic hypoglycemia. Control fetuses responded to both leucine and lysine infusions with increased arterial plasma insulin concentrations (average increase: 0.1...
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This study aimed to determine whether exposure of the oocyte and/or embryo to maternal undernutrition results in the later programming of insulin action in the liver and factors regulating gluconeogenesis. To do this, we collect livers from singleton and twin fetal sheep that were exposed to periconceptional (PCUN; -60 to 7 days) or preimplantation (PIUN; 0-7 days) undernutrition at 136-138 day...
متن کاملA physiological increase in insulin suppresses muscle‐specific ubiquitin ligase gene activation in fetal sheep with sustained hypoglycemia
Decreased glucose transfer to the fetus is characteristic of pregnancies complicated by maternal under nutrition and placental insufficiency. Chronic experimental restriction of glucose transfer to the sheep fetus for the final 40% of gestation with a maternal insulin infusion (HG fetuses) results in fetal hypoglycemia, hypoinsulinemia, and decreased rates of fetal growth and protein accretion ...
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تاریخ انتشار 2008